The paper said that the teens, one of whom injured a knee and the other suffered a broken collarbone, were staying at a hotel arranged by the Red Cross.
Lt. Gregg Hastings said the bus crashed along the west end of the Blue Mountains, and west of an area called Deadman Pass. The area is well known locally for its hazards, and the state transportation department advises truck drivers that "some of the most changeable and severe weather conditions in the Northwest" can lead to slick conditions and poor visibility. Drivers are urged to use "extreme caution and defensive driving techniques," and warned that snow and black ice are common in the fall through the spring.
The bus had been carrying about 40 people. St. Anthony Hospital in Pendleton treated 26 of them, said hospital spokesman Larry Blanc. Five of those treated at St. Anthony were transported to other facilities.
Blanc did not elaborate on the nature of the injuries but told the Oregonian that the hospital brought in additional staff to handle the rush of patients and did a lot of X-ray imaging.
I-84 is a major east-west highway through Oregon that follows the Columbia River Gorge.
Umatilla County Emergency Manager Jack Remillard said the bus was owned by Mi Joo travel in Vancouver, B.C., and state police said the bus was en route from Las Vegas to Vancouver.
A woman who answered the phone at a listing for the company confirmed with The Associated Press that it owned the bus and said it was on a tour of the Western U.S. She declined to give her name.
A bus safety website run by the U.S. Department of Transportation said Mi Joo Tour & Travel has six buses, none of which have been involved in any accidents in at least the past two years.
A spokesman for the American Bus Association said buses carry more than 700 million passengers a year in the United States.